I voted "I expect so"... though I'm not just a simulator Cessna pilot, I think myself quite capable in the hands of a Level D 763, and all across the PMDG, plus I'm an instructor at Flight Experience so feel pretty comfortable in the cockpit compared to the usual click of a mouse on a screen. I think the hardest thing would be the 'seat of your pants' feeling, and the view out the window (ie how high from the ground are we really going to hit the deck, when do I initiate my flare?).
That and your possible impending death would be the hardest things to overcome. Flight simmers know the theory better than anyone other than the real pilots, but putting it into practice in a completely unfamiliar aircraft, under completely stressful circumstances, even then I don't know how I'd stack up. And that's exactly what I tell my flight experience customers when they are surprised how much I know despite not even having a PPL
As for autolands James, very few aircraft have them, and from memory, I believe not every airport is capable. Maybe even only a few airports are of the correct category to allow aircraft to auto land on them. Otherwise we'd have no problems when Auckland is fogged out as the aircraft landing there are capable (eg Emirates B773 or Thai A346 etc)
The runway isn't qualified

Perhaps Towerguy might know a little about this?